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16 min 29 sec
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The Age of Diagnosis: How Our Obsession with Medical Labels Is Making Us Sicker

A London neurologist shows when medical labels and genetic tests help and when they harm. She gives you the questions to ask before a diagnosis or a risk score reshapes your life.

Table of Content

If a diagnosis has ever brought you relief, or a test result filled you with dread about a future that had not arrived, you already live in the world this book examines. In The Age of Diagnosis, London neurologist Suzanne O’Sullivan argues that medicine can now name more conditions than ever, and that this power shapes how people feel and live as much as how they are treated. A label can open a clinic door and bring real relief. It can also turn a risk into surgery, and uncertainty into an identity.

Her case is that a diagnosis is only as good as the context, evidence and probabilities behind it. She tests that case on families facing Huntington’s disease and cancer genes, on contested conditions such as Lyme disease and long Covid, and on the fast rise of autism and ADHD diagnoses, showing where naming helps and where it harms. What you gain is a short set of questions to ask before any test or label reshapes your life.

A single blood test can tell a healthy thirty-year-old whether an incurable disease is coming. Most people offered that knowledge turn it down, and their reasons reveal what prediction can do to the present.

A positive test at 25 led one young woman to surgery that cut her cancer risk dramatically. Her story shows what that choice gave her, what it cost, and why the uncertainty never fully left.

In one recent year, hundreds of thousands of Americans were treated for an infection far fewer could be shown to have. The gap between the count and the evidence shows what happens when a label outruns its proof.

Autism diagnoses among American children have risen from a few in ten thousand to about one in 36. The explanation is not the one many people assume, and the change carries a cost that rarely gets discussed.

An ADHD diagnosis can explain years of struggle in a single afternoon. What happens next may depend on something no prescription can supply: how the label fits into the story you tell about yourself.

A whole genome can now be read in about a day. Working out what the letters mean is far slower, and families waiting for answers often live in the gap between the two.

Every story here turns on the same tension. Valentina’s test, Roisin’s surgery and a child labeled SWAN all involve real information. Each also risks letting a probability feel like a fate, or letting a label crowd out stress, history and ordinary life. O’Sullivan’s warning is about speed: reaching for a name faster than the understanding behind it.

Her book points to a few habits for the next time a test or label is offered to you or someone close to you. Ask what the answer would change, and how often a result like it turns out to be wrong. Before accepting a broad label, look at what else in your life, from sleep and stress to isolation, might explain how you feel. If a diagnosis does arrive, let it describe what you are facing while your relationships, routines and energy remain the real measure of progress.

Slowing down keeps a label in its proper place, as a tool for timely help that leaves your options open.

About this book

What is this book about?

Medicine can name more conditions than ever, from gene variants that predict disease decades ahead to broad labels for fatigue, distraction or social difficulty. Suzanne O'Sullivan, a neurologist in London, argues that this power now shapes how people see themselves as much as how they are treated. A diagnosis can open doors to care and bring real relief. It can also turn healthy people into patients, harden uncertainty into identity and push risk toward surgery. O'Sullivan builds her case on patients' stories, among them a woman whose mother developed Huntington's disease and a 25-year-old who chose surgery after a BRCA1 result. She examines predictive genetics, cancer screening, Lyme disease and long Covid, the steep rise in autism and ADHD diagnoses, and the gap between how fast genomes can be read and how well they can be understood. Readers come away with a clear way to think about tests and labels. Weigh probabilities honestly. Put the whole personal context ahead of a single result. Treat a diagnosis as a tool for timely help, and keep it from becoming a fixed verdict on who you are.

Book Information

Rating:

Genre:

Health & Nutrition

Topics:

Medicine

Publisher:

Penguin Random House

Language:

English

Narrator:

Cole

First published:

March 18, 2025

Pages:

320

Length:

16 min 29 sec

Get the book:

Amazon

Who it's for

  • Weighing genetic risk

    People weighing a genetic test or living with a family history of serious disease.

  • Adults weighing a diagnosis

    Adults considering, or recently given, an autism or ADHD diagnosis who want a clear view of what it offers.

  • Patients and their caregivers

    Patients with lingering symptoms labeled as Lyme disease or long Covid, and the people caring for them.

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About the Author

Suzanne O'Sullivan

Suzanne O'Sullivan was born in Dublin and works as a neurologist at the National Hospital for Neurology and Neurosurgery in London. She began writing in her forties and draws on cases from her own practice, with details disguised. Her first book, It's All in Your Head, won the 2016 Wellcome Book Prize and the Royal Society of Biology General Book Prize. She has since written Brainstorm, about epilepsy, and The Sleeping Beauties, about mass psychogenic illness.

Ratings & Reviews

Ratings at a glance

4.5

Overall score based on 123 ratings.

What people think

Listeners describe this as a stimulating and demanding examination of contemporary healthcare, even if views are mixed regarding the author’s polarizing approach to chronic conditions and neurodiversity. Furthermore, many listeners value the way the text poses vital inquiries into "diagnosis creep" and the hazards of turning standard human differences into medical issues. They also highlight the perceptive evaluation of predictive genetics, where one listener observes that the Huntington’s disease section provides a profoundly compassionate perspective on the conflict between certain knowledge and optimism. Finally, they note that the writing functions as a potent catalyst for discussion, with one reviewer labeling it an "incredibly important" volume that pushes the public to reconsider its dependence on labels.

Top reviews

Mattanee

Few books manage to be this unsettling while remaining profoundly compassionate toward the human condition. O’Sullivan expertly dissects the phenomenon of "diagnosis creep," where the boundaries of what we consider "normal" are constantly shrinking to accommodate new labels. Her analysis of how we've started pathologizing everyday sadness and social friction is timely. I was particularly struck by the section on predictive genetic testing—it makes you realize that "certainty" in medicine is often an illusion that breeds more anxiety than relief. The writing is sharp, though the sentence structure can feel a bit breathless at times. It’s a necessary challenge to the "more is better" approach to modern healthcare. Truth is, we might be making ourselves sicker just by looking for names for our imperfections. A vital, if polarizing, read for anyone navigating the current medical landscape.

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Brooklyn

O’Sullivan has written a vital manifesto for the modern patient that refuses to offer easy answers. She explores the "recovery identity" with such nuance, arguing that sometimes a diagnosis can become a cage rather than a key. The way she contrasts the definitive horror of Huntington’s with the murky, expanding definitions of ADHD and depression is masterfully handled. I found the section on how society demands these labels—for benefits, for school accommodations, for work—to be the most illuminating part of the book. It’s not just a medical issue; it’s a cultural shift. Her prose is direct and often quite blunt, which I appreciated, even when the subject matter became uncomfortable. It’s rare to find a doctor willing to speak so candidly about the limitations of their own profession. This book should be required reading for anyone entering the medical field.

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Pete

The chapter on Huntington’s disease stayed with me long after I closed the cover. O’Sullivan writes with a level of empathy that I haven't seen in many medical texts, particularly when discussing the agonizing choice between knowing your fate or living in hope. She tackles the "age of diagnosis" not just as a medical trend, but as a crisis of meaning. We use these labels to legitimize our pain because we live in a world that doesn't know how to handle suffering without a code. I loved her insistence that a doctor's ears and eyes are still more powerful than any genetic sequence or high-tech MRI. It’s a call to return to a more human form of medicine. The pacing is excellent, and she manages to make complex neurological concepts accessible without being patronizing. Truly a standout non-fiction title for the year.

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Tippawan

After hearing so much buzz about this, I finally got around to reading it, and wow—it's a punch to the gut. O’Sullivan isn't just criticizing medicine; she’s criticizing our collective inability to accept that being human is often uncomfortable. Personally, I found her take on predictive medicine to be the most chilling part, where we spend our "healthy" years waiting for a disease that might never manifest. It’s written with a clarity that is rare in the medical field, and it manages to be both a critique and a celebration of human variance. Some might find her tone a bit defensive, but I saw it as a doctor trying to protect her patients from the harm of over-medicalization. If you want a book that makes you question everything you think you know about health, this is it. It’s incredibly important for our current cultural moment.

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Tanyaporn

Is more medicine always better? That is the haunting question at the center of this provocative work by neurologist Suzanne O’Sullivan. She dives deep into the messy world of "incidentalomas"—those tiny anomalies found on scans that might never cause a problem but lead to a lifetime of unnecessary treatment. While I didn't agree with every point, especially regarding neurodiversity, her argument for prioritizing clinical judgment over a battery of automated tests is compelling. The book is well-researched, though it occasionally drifts into a defensive tone when addressing potential critics. Frankly, the distinction between a "roadmap" diagnosis and an "identity" diagnosis is one we need to discuss more openly in our society. It's a dense read, but one that rewards those willing to have their assumptions challenged about what it means to be truly healthy in an age of constant screening.

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Orawan

Picked this up after seeing Chris Van Tulleken’s blurb on the cover, and it definitely lived up to the hype, though it's bound to ruffle some feathers. O’Sullivan is a neurologist who isn't afraid to ask why we are so desperate for medical explanations for every quirk of our personalities. The style is very readable, almost like a series of medical mysteries, but with a philosophical edge that keeps you thinking. Look, I get why people are upset about her take on neurodiversity—she can be quite sharp—but her point about "medicalizing difference" is an important one. We are losing our tolerance for human variance. Some chapters felt a bit repetitive, and the lack of commas made me re-read a few sentences to catch the meaning, but the core message is solid. It’s a brave look at how we’ve replaced community support with clinical codes. Not perfect, but worth your time.

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Dylan

As someone who works in the healthcare sector, I found this perspective on "the power of suggestion" and "illness identity" incredibly refreshing. O’Sullivan doesn't shy away from the fact that our diagnostic tools are often used as sticking plasters for deeper societal issues. The way she details the transition from "variant of normal" to "disorder" is chillingly accurate. However, I do think she occasionally overlooks how life-saving these labels can be for those who have been gaslit by the system for years. The chapter on "Syndrome Without a Name" was a highlight for me, offering a compassionate look at the limbo patients inhabit when science fails to provide a box for them to fit into. It’s a dense, intellectual journey that asks us to value clinical nuance over the binary of "sick" or "healthy." A bit academic in spots, but the anecdotal case studies keep it grounded in reality.

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Chamlong

We live in a culture obsessed with labels, and this book serves as a much-needed reality check. Suzanne O'Sullivan argues that by constantly expanding diagnostic criteria, we are actually diluting the resources available for those with the most severe forms of illness. It’s a controversial stance, but she backs it up with some pretty staggering statistics about cancer over-diagnosis and the rise of "asymptomatic" diseases. My only real gripe is that she doesn't spend enough time on the role of social media or the crumbling state of public health services, which I think drives a lot of this self-diagnosis. Still, her point about "pathologizing the environment" is spot on. We look for a chemical imbalance when we should be looking at our broken social structures. It’s a challenging read that will make you rethink your last Google symptom search.

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Benjamin

This was a bit of a slog in parts, mostly due to some questionable structural choices. Why on earth are Lyme disease and Long Covid shoved into the same chapter with a tenuous link about self-diagnosis? It felt like the author had a specific axe to grind and bent the narrative to fit her thesis. To be fair, her exploration of Huntington's and the ethics of knowing your genetic future was absolutely top-notch—deeply moving and intellectually stimulating. But then you get to the ADHD and Autism sections, and it feels like she’s speaking a completely different language, one that ignores modern understandings of the spectrum. It’s a book of two halves: one brilliant and empathetic, the other dismissive and bordering on "quackery" in its suggestions for the cure for depression. I’m giving it three stars because the good parts are truly excellent, but you have to filter out a lot of bias.

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Wit

Not what I expected at all, and frankly, quite damaging. While O’Sullivan raises some fair points about over-testing in oncology, her dismissive attitude toward Long Covid and ADHD felt incredibly reductive. To suggest that these conditions are largely psychosomatic or fueled by a "need for labels" ignores the lived reality of millions. The chapter where she lumps Lyme disease and Long Covid together felt particularly lazy; it’s a bizarre editorial choice that undermines the scientific rigor she claims to uphold. I felt a palpable lack of empathy for patients who have spent years fighting to be heard by doctors who share her exact biases. If you’re currently struggling with a chronic illness or navigating a new neurodivergent diagnosis, please be careful with this one. It feels like a step backward for patient-centered care, placing blame on the individual rather than looking at the systemic failures of our healthcare system.

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Questions about this book

Suzanne O’Sullivan argues that medicine can now name more conditions than ever, and that labels shape how people feel and live as well as how they are treated. A diagnosis can bring relief and open access to care, but when tests and labels outrun understanding, they can turn risk into treatment and uncertainty into identity. Her answer is to ground every diagnosis in context, honest probabilities and evidence.

She links the rise mainly to broader definitions, uneven assessment and cultural incentives, and sees no hidden epidemic. Autism prevalence in American children went from about 4 in 10,000 to about 1 in 36. She accepts that many adults find a diagnosis validating, but notes that long-term benefits are rarely studied and warns that intensive support must stay protected for those with the greatest needs.

The book does not say yes or no. It shows that a result cannot be unlearned and can make ordinary slips feel like early disease, the nocebo effect. Most adults at risk of Huntington’s disease decline testing after counseling. O’Sullivan stresses counseling, clinical confirmation of any positive result, and realistic odds, since gene variants such as BRCA1 raise risk without guaranteeing illness.

Before any test, ask what the answer would change and how often such results are wrong. Before accepting a broad label, consider what else in your life, such as stress, isolation or poor sleep, could explain your symptoms. If you do receive a diagnosis, O’Sullivan favors a recovery identity: measure progress through steadier relationships, lasting routines and regained energy, and try treatments for a set period.

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The Age of Diagnosis

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